PHYSICAL EXERCISE 11
Activity of Acetylsalicylsaure
(Acetylsalicylic Acid from Salicylic Acid)
RAQUID, Rency T
Group a few
My spouse and i. Introduction
Due to the demand of certain reagents in the clinical in order to perform and carry out further experiments or develop essential chemical substances, chemists consistently develop organic and natural synthesis. This method aims to make and synthesize desired organic and natural compounds via commercially or readily available types by providing the best route in synthesizing the compound. One example of a chemical substance being could be synthesized in the laboratory can be acetylsalicylic acid solution, commonly known as acetylsalicylsaure. It is variedly used for different purposes: an analgesic to ease minor body pains which includes headaches; a great anti-inflammatory medicine; and as a great antipyretic to reduce fever. The usage of this drug goes back in historical times, roughly in the second millennium, the moment Egyptians utilized willow tree (bark) and other salicylate rich plants because pharmacological individuals. In the nineteenth century, pharmacists conducted experimentations regarding the medicinal properties of salicylic chemical p. It was not really until 1853, that the German chemist Frederic Gerhardt produced acetylsalicylic acid solution (a stronger form) by making use of acetyl chloride and salt salicylate. This breakthrough gave chemists a method for learning the chemical substance structure of the compound and even more efficient ways of synthesis which have been cheaper and shorter. The physiological function of aspirin can be attributed in its capability to interfere with the availability of prostaglandins, a the natural way secreted chemical substance by the human body which causes discomfort, headaches and blood coagulation. The latter is in reality a downside of the drug, as a result of possible serious blood loss of patients whom are frequently using the drug. Yet also, this property of aspirin can be useful for the prevention of bloodstream clots in the blood vessels and the brain which can be fatal. Acetylsalicylic acid is really an ester derivative of salicylic acidity. Esters will be produced through reactions including acid anhydrides and alcohols. In this try things out the starting material in synthesizing aspirin is salicylic acid. To prepare aspirin, salicylic acid is definitely reacted with an excess of acetic anhydride. A bit of a strong chemical p (phosphoric acid) is used as being a catalyst which in turn speeds up the reaction. The excess lactic acid will be hydrated by adding water. The reaction of synthesis will certainly proceed simply by nucleophilic acyl substitution. Thisis simply the replacement of oneВ nucleophileattached into a carbonyl group with another. For the synthesis of aspirin coming from salicylic acid solution, acetic anhydride will be the acyl component beingnucleophilically substituted. В The nucleophile mounted on the acyl group that is being changed is the acetate ion (CH3COO-). The new nucleophile attacted to the acyl group is salicylic acid, the substrate that is getting acylated. Beneath is the synthesis reaction:
Since acetic acid is very soluble in normal water, it is easily separated in the aspirin product by the addition of drinking water. This isolates the elementary product, which can be purified by recrystallization, employing ethanol while solvent and cold dH2O as the agent for recrystallization. To verify and test the purity with the synthesized aspirin, melting stage (instrinsic property) is used. The melting level of acetylsalicylic acid runs from 138 to 150 degree Celsius. If pollutants and impurities are present inside the sample, there is discrepancies inside the value in the melting level of the compound.
This experiment should:
1 . to describe the concept of organic and natural synthesis
installment payments on your to synthesize acetylsalicylic acid from salicylic acid by nucleophilic acyl substitution; and 3. to explain and make clear differences in the properties of acetylsalicylic acid solution and salicylic acid by simple chemical substance tests.
III. Materials and Methods
A. Schematic Picture
(+) 3mL acetic anhydride
(+) a few drops H3PO4
Referrals: Brown, Lemay and Bursten(2009). Chemistry: The Central Scientific research 11th education. Prentice Hall, 534-537.
Trademark Organic Hormone balance and All-natural Products (2004). Basic Organic Chemistry Clinical Manual. 10th ed. Institute of Biochemistry and biology, College of Arts and Sciences, College or university of the Israel Los BaГ±os.
History of Aspirin (2013). Gathered on March 5, 2013 from http://en.wikipedia.org/wiki/History_of_aspirin
McMurry, 3rd there’s r. S. (2008). 7TH Ed. Organic Biochemistry and biology. USA: Prentice Hall, 332-345.
Rodriguez, Elizabeth. B. (1997). Basic Principles of Organic Biochemistry. UP Wide open University: Diliman Quezon Metropolis. 295 вЂ“ 336.
Telow, A. L. V. ou al. Recovered on The fall of 24, 2014 from https://www.academia.edu/
IX. Remarks and Suggestion
Organic activity is indeed essential to the contemporary society now these days, especially we are now going into an era details of technology. Chemists and scientists have to develop different options on how to synthesize unobtainable or rarely occurring substances, just for this will enable us to comprehend more about how chemical procedures and communications helps us in our each day lives.
Experts recommend to various other researchers that would work on the synthesis of aspirin to develop more ways and method in synthesizing and isolating the said compound which are significantly less error vulnerable, efficient, less expensive and period saving.